TRIMETHOPRIM LACTATE SALT

PRODUCT IDENTIFICATION

CAS NO. 23256-42-0

TRIMETHOPRIM LACTATE SALT

EINECS NO. 212-006-2
FORMULA C14H18N4O3·C3H6O3
MOL WT. 380.40

H.S. CODE

 

TOXICITY

 

SYNONYMS  
Lactic acid with 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine (1:1); Milchsäure, Verbindung mit 5-(3,4,5-Trimethoxybenzyl)pyrimidin-2,4-diamin (1:1) (German); ácido láctico, con 5-(3,4,5-trimetoxibencil)pirimidina-2,4-diamina (1:1) (Spanish); Aacide lactique, composé avec 5-(3,4,5-triméthoxybenzyl)pyrimidine-2,4-diamine (1:1) (French); 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine Lactate salt;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellowish powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH 4 - 6
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION AND APPLICATIONS

Trimethoprim, an antibacterial drug, is a bacterial dihydrofolate reductase inhibitor used as a prophylactic or to treat various bacterial infections particularly urinary tract infections such as Proteus mirabilis, Escherichia coli, and Klebsiella species as well as Pneumocystis carinii and traveler's diarrhea. Folic acid is essential for hematopoiesis. It is reduced to dihydrofolic acid and then tetrahydrofolic acid , the parent compound of the derivatives that act as coenzyme carriers of one-carbon groups in various metabolic reactions. In result, trimethoprim interferes the synthesis of tetrahydrofolic acid resulting the inhibition of the DNA nucleoside synthesis. It is usually used in combination with a sulfonamide drug, sulfamethoxazole for synergistic effect. The molecular structure of sulfonamide class antimicrobial agents is similar to p-Aminobenzoic acid (PABA) which is needed in bacteria organisms as a substrate of the enzyme dihydropteroate synthetase for the synthesis of tetrahydrofolic acid (THF). Sulfonamides are capable of interfering with the metabolic processes in bacteria that require PABA. The combination drug interferes with sequential steps in the metabolism of certain bacteria.  But the use of sulfamethoxazole is declining due to reports of sulfamethoxazole bone marrow toxicity. The trade names of the combined product are Bactrim and Septra. The chemical designation of trimethoprim is 5-[(3, 4, 5-trimethoxyphenyl)methyl]-2, 4-pyrimidine diamine. It is a white to yellowish compound with bitter taste.  Sulfamethoxazole is 4-amino-N-(5-methyl-3-isoxazolyl) benzenesulfonamide or (N1-(5-methyl-3-Isoxazolyl) Sulfanilamide). It is an white to off-white compound, odorless, tasteless. Dapsone (4,4'-sulfonylbisbenzenamine) is a parent compound in preparing sulfonamide antibacterial agents such as acedapsone, acetosulfone, glucosulfone, sulfoxone and solapsone. Dapsone and its derivatives have bacteriostatic activity against a broad spectrum of gram-negative and gram-positive organisms. Dapsone is a primary treatment for Dermatitis herpetiformis and in the treatment of leprosy (Mycobacterium leprae infections) leads to apparent improvementas. It is used in the prophylaxis of falciparum malaria. It is a white crystalline powder; melting point 175 - 180C; insoluble in water and vegetable oils. Pentamidine is also used for the patients who are allergic to trimethoprim or sulfamethoxazole. Pentamidine is an antiprotozoal agent used as the isethionate salt to preventi and treat diverse phylum of eukaryotic microorganisms. It is a nonpyrogenic, lyophilized product. Pentamidine isethionate is a white crystalline powder; soluble in water and glycerin; insoluble in ether, acetone, and chloroform. The chemical designation is 4,4'- diamidino-diphenoxypentane di(beta-hydroxyethanesulfonate).
SALES SPECIFICATION

BP/EP/CP/USP

APPEARANCE

white to yellowish powder

ASSAY

98.5 - 101.5%

LOSS ONDRYING

2.0% max

TRANSPORTATION
PACKING 25kgs in fiber drum
HAZARD CLASS 3 (Packing Group: III)
UN NO. 2811
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 61-23/24/25-43, Safety Phrases: 53-22-36/37/39-45